NMN intrinsically safe
NMN (Nicotinamide mononucleotide) is a naturally occurring biologically active nucleotide that is involved in a wide range of biochemical reactions in the human body and is closely related to immunity and metabolism.
In human body, NMN is the most direct precursor of NAD+, and its function is reflected by NAD+.
NAD+, also called coenzyme I, is fully known as nicotinamide adenine dinucleotide and is present in every cell involved in thousands of reactions. The nicotinamide adenine dinucleotide (NAD) molecule plays an important role in a wide range of cellular metabolic reactions and is an essential support for cells to maintain viability.
The decline of NAD during aging is considered to be a major cause of disease and disability, such as hearing and vision loss, cognitive and motor dysfunction, immune deficiency, arthritis due to dysregulated autoimmune inflammatory response, metabolic disorders and cardiovascular disease.
Therefore, NMN supplementation increases NAD+ content in the body, thereby delaying, improving, and preventing various aging-related phenotypes, or age-induced metabolic disorders, senile diseases, etc.
NMN is found in breast milk and natural foods
NMN is inherent in the human body and is widely found in breast milk and foods, including common broccoli, cabbage, cucumber, snap peas, avocados, etc.
The NMN content in food is too low to meet the needs of the human body. The following is the NMN content in various foods:
According to experimental data, the amount of NMN needed by an adult is 8mg/kg/day. Taking a 70KG adult as an example, the body needs 560mg of NMN every day.
The human body can synthesize part of it, and the part that needs external supplementation should reach 200-300 mg. The older you are, the more external supplements you need.
Supplementing the same amount of NMN through food is equivalent to eating 20-30kg of edamame every day. This is obviously impossible.
NMN authoritative human clinical trials confirm safety
In recent years, in order to study the impact and safety of NMN on human physiology, major scientific research institutions around the world have carried out a number of studies.
In January 2020, Japan's Keio University publicly stated that after 4 years of human clinical trials, it has been proved that NMN taken within 500 mg per day can be efficiently absorbed by the human body without side effects.
NMN production process safety
There are three main production methods of NMN, which are chemical synthesis method, microbial fermentation method and biological enzyme method.
Chemical synthesis method: Catalysts will be added during the production of NMN, resulting in more harmful substances such as heavy metals in the finished product.
Microbial fermentation method: use microorganisms to convert them into NMN products that people need through specific metabolic pathways, but this method is slow in conversion and low in production efficiency.
NMN has no side effects
Studies have proved that supplementing NMN will not affect the activities of various enzymes in the supplementary synthesis pathway. After oral administration of NMN, it has no effect on the activities of various enzymes in the supplementary synthesis pathway, such as NAMPT, PARP, and NMNAT. It directly changes the level of NAD+ in the body.
Taking the right amount of NMN is only an effective supplement for the inevitable natural deficiency reduction of the amount of NMN originally contained in the human body.
We can understand taking NMN as calcium supplementation: with age, bone density will decrease. At this time, it is necessary to regulate the calcium level of the body through long-term calcium and vitamin D supplementation so as to prevent a series of bone fractures such as osteoporosis and fractures. Health problems, therefore, we need additional calcium for the body.
The same principle applies to the use of NMN: as the human body ages, the NAD+ level decreases, and many biochemical metabolic reactions in the human body cannot be carried out efficiently, leading to an increase in disease susceptibility, so the older you are, the more health problems you have. At this time, we need to supplement NMN for a long time to maintain the body's NAD+ level.
If you would like to take or purchase some NMN Powder, please contact us at chriswang@sheerherb.com.
