L-Glutamine Powder

Glutamine is the amide of glutamic acid. L-glutamine is an encoded amino acid in protein synthesis. It is a non-essential amino acid in mammals and can be converted from glucose in the body. Glutamine can be used to treat gastric and duodenal ulcers, gastritis and hyperacidity, and to improve brain function. Store in a sealed and ventilated place.

Use 1: Used in biochemical research, used in medicine for diseases such as peptic ulcer, mental disorder, alcoholism, and brain dysfunction in epilepsy patients, and used to improve children with mental retardation.
Use 2: Nutritional supplements, flavoring and flavoring agents. It is used in medicine to treat peptic ulcer, alcoholism and improve brain function.
Use 3: This product is transformed into glycosamine in the body, as the precursor of mucin synthesis, it can promote ulcer healing, and it is mainly used as a medicine for peptic ulcer. In addition, it can also be used as a brain function improver and for the treatment of alcoholism.
Use 4: biochemical research, bacterial culture medium.

L-glutamine widely exists in nature, for example, it is contained in pumpkin and sunflower seedlings in a free state, and its N-ethyl compound (theanine, theanine) is contained in tea leaves. While glutamine can be extracted from natural products, it is produced in large quantities by fermentation and synthesis.
1. Synthesis method
The is obtained from L-glutamic acid-5-methyl ester ([1499-55-4]) through condensation, addition, salt formation and hydrolysis. Glutamic acid is esterified with methanol in the presence of concentrated sulfuric acid, and the resulting esterified solution is added dropwise into a mixture of methanol and carbon disulfide, and ammonia is passed under cooling while adding dropwise. After the esterification solution was added dropwise, continue to pass through ammonia, then add triethylamine, and place it in a closed place at 30°C for 40h. After being concentrated under reduced pressure to catch ammonia, the concentrated solution of γ-methyl ester-L-glutamic acid-N-diammonium carbamate was obtained. It was heated to 40-45°C and acetic acid was added. After stirring for 30 min, carbon disulfide was removed under reduced pressure, and a large amount of crystals were precipitated at this time. Then add an equal volume of methanol, place at 0°C for 12h, filter to obtain crude glutamine. Decolorized by activated carbon and recrystallized to obtain the finished product.
2. Fermentation method
Glucose, acetic acid, and ethanol are used as the carbon source of the medium, and Brevibacterium flavum is used for fermentation. The yield based on glucose is 39g/L, and the yield is 39%.