Lemairamin

Lemairamin (also known as wgx-50) is isolated from the peel of the Zanthoxylum plant. As an agonist of α7 nicotinic acetylcholine receptors (α7nAChRs), it reduces neuroinflammation in Alzheimer's disease. The data showed that subcutaneous remopramine dose-dependently suppressed formalin-induced tonic pain but had no effect on acute pain sensation in mice and rats, whereas intrathecal remopramine had no effect on neurological and Mechanical antihyperalgesia was also dose-dependently produced in the ipsilateral hind paw of rats with bone cancer pain, without affecting mechanical thresholds in the contralateral hind paw. Twice daily injections of Lemairamin do not induce mechanical antiallodynia in neuropathic rats. Intrathecal lemairamin also stimulated the expression of IL-10 and β-endorphin in the spinal cord in a manner reversible by α7nAChR antagonists, and lemairamin treatment induced the expression of IL-10 and β-endorphin in spinal cord microglia. In addition, intrathecal injections of the microglial activation inhibitor minocycline, anti-IL-10 antibodies, anti-β-endorphin antiserum, or the mu opioid receptor-preferred antagonist naloxone were able to block neuropathic pain Mechanical antihyperalgesia induced by lamellamine in . These data suggest that following α7nAChR activation, Lemairamin can produce antinociception in pain hypersensitivity via the spinal IL-10/β-endorphin pathway.

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