Oleanolic Acid

Oleanolic acid is a naturally occurring pentacyclic triterpenoid found mainly in fruits and vegetables. It has been reported to have various pharmacological activities, such as anti-inflammatory, anti-hyperlipidemic, antioxidant, antiviral, hepatoprotective, antitumor, antibacterial, and antidiabetic activities. It was also shown to inhibit AGEs, thereby conferring kidney protection in STZ-induced diabetic mice through anti-glycation.

1. Reduce liver damage: Oleanolic acid is a pentacyclic triterpenoid compound, which has obvious protective effect on acute and chronic liver damage in rats caused by carbon tetrachloride. After treatment, enlarged mitochondria and expanded rough endoplasmic reticulum were restored. It can also significantly reduce the hepatocellular ballooning degeneration, necrosis and inflammatory response of acute and chronic liver injury. The accumulation of triglycerides in the liver decreases and the amount of glycogen increases.

2. Reduce serum alanine aminotransferase activity: oleanolic acid has obvious enzyme-lowering effect on animals with acute and chronic hepatitis and liver cirrhosis.

3. Reduce serum r-globulin, which is consistent with the reduction of liver-related inflammatory reactions seen in histological observations.

4. Promote the regeneration of liver cells: oleanolic acid can significantly increase the number of mitotic phases in the residual liver of rats, and the degree of regeneration is higher than that of the control group, suggesting that it has the effect of promoting cell regeneration.

5. Decrease the level of tyrosine in the brain homogenate of rats with liver cirrhosis: Since the level of tyrosine in the brain homogenate is significantly reduced, it can inhibit the generation of false neurotransmitters, so it is beneficial to the prevention and treatment of hepatic encephalopathy.

6. Inhibition of liver fibrosis: In rats with liver fibrosis treated with oleanolic acid, the liver fibrosis was severe and significantly reduced, and the content of liver collagen decreased, suggesting that it has the effect of preventing and treating liver cirrhosis.

7. Oleanolic acid has obvious inhibitory effect on mouse mononuclear phagocyte system, macrophage phagocytosis and experimental arthritis, but has an effect on heterosexual humoral immune function and antigen-binding cells. Enhance immunity and inhibit the growth of S180 tumor strain.

8. It has a protective effect on chromosome damage, prevents experimental atherosclerosis, and can correct protein metabolism disorders.

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