Fisetin Supplement

Fisetin, also known as fisetin or fisetin, is a flavonol derived from plants. Fisetin was first extracted from sumac (German: Fisetholz) by Jakob Schmid in 1886, so it is also called sumacin. Since sumac belongs to the Anacardaceae family, fisetin is also called sumac flavonoids. Its chemical formula was first determined by Josef Herzig in 1891. Fisetin is a common plant pigment found in many common vegetables and fruits such as strawberries, apples, persimmons, onions and cucumbers.

One of the flavonoids in particular has been studied, fisetin. It is theorized that fisetin is a flavonol molecule similar to the flavonols found in dark chocolate and cocoa. Trace amounts of fisetin can also be found in certain fruits and vegetables.
Based on existing research, strawberries are found to be particularly high in fisetin, followed by apples. The content of fisetin in strawberries is about five times that in apples, and it is generally more than thirty times that in mangoes, kiwis, grapes, tomatoes, onions, cucumbers and various nuts.
However, the levels of fisetin in these foods are still not high enough to compare with the levels of fisetin in dietary supplements. In Japan, the estimated average daily intake of fisetin is 0.4 mg. As a dietary supplement, the recommended daily dose of fisetin should be 100 mg.

● Stimulates and assists brain circuits and brain signaling pathways involved in long-term memory function
Much of the research on fisetin for brain health has been conducted at the prestigious Salk Institute for Biological Studies in San Diego, focusing on fisetin as a "nootropic" and "neurotrophic factor" to study. The so-called "nootropic substances" refer to substances that can strengthen memory and brain function. Several other natural compounds that play this role include Hericium erinaceus extract, PQQ with CoQ10, resveratrol, and curcumin.
What sets fisetin apart is its role as a neurotrophic factor. This class of compounds supports the survival, differentiation, and maintenance of function of brain cells. In other words, what makes fisetin different is that, in addition to helping brain cells function better, as a neurotrophic agent, fisetin also plays a role in optimizing what's known as "brain plasticity." Brain plasticity refers to the brain's ability to respond to develop new or restore old brain circuits. Brain plasticity is important for normal brain functions such as learning and memory. Therefore, by acting as a neurotrophic agent to optimize brain plasticity, fisetin can actually lead to optimization of brain circuits and brain signaling pathways related to long-term memory function.
Of all the flavonoids tested and applied in animal models of age-related brain changes, only fisetin and a related trace flavonol proved to be superior.