Fisetin 98%

What is Fisetin?
Fisetin is a flavonoid that is considered an antiaging drug, meaning it kills aging cells. According to rodent studies, it may reduce the number of aging cells in tissues and prolong life. Fisetin is a flavonoid compound, which is insoluble in water, carbon tetraoxide and petroleum ether, and soluble in dry acetone and acetic acid and other solvents, which widely exist in fruits and vegetables such as strawberries, apples, onions, cucumbers, etc., have a wide range of sources, are cheap and easy to obtain, and have a wide range of pharmacological activities, such as anti-inflammatory, anti-oxidation, anti-bloody, anti-thrombotic, pain relief , treatment of diabetic kidney damage, etc.

The efficacy of Fisetin：
● Antioxidant weapon and inflammation killer
In 1966, an article published in "Nature" stated that fisetin was one of the flavonoids with the strongest antibacterial effect known at that time, and only 50 μg/ml was needed to effectively inhibit the growth of bacteria such as Staphylococcus aureus. This has caused scientists to pay attention to the pharmacological effects of fisetin. In follow-up research on fisetin, scientists discovered that it has antioxidant and anti-inflammatory effects.
As a flavonoid, fisetin has natural antioxidant properties. It not only has direct antioxidant activity, but also increases the level of the main antioxidant glutathione in cells. Even in the case of oxidative stress, fisetin can maintain mitochondrial function well, and even very fragile neuron cells can be well protected.

In addition to its own antioxidant talent, its anti-inflammatory effect should not be underestimated. Fisetin inhibits the NF-κB pro-inflammatory signaling pathway by activating β-catenin protein and silencing the expression of TLR4, and then down-regulates the release of inflammatory cytokines to achieve anti-inflammatory effects.
● Tumor nemesis
For the powerful fisetin, anti-oxidation and anti-inflammation are nothing but basic operations, and fighting tumors is its stage. Fisetin plays an inhibitory role in all stages of tumor development, using its "thunderbolt" method to treat tumors subduedly.

In the early stages of tumors, fisetin can interfere with the separation of chromosomes and promote DNA double-strand breaks, thereby reducing their proliferation rate. During the period of rapid tumor growth, fisetin can also reduce angiogenesis by inhibiting uPA (urokinase plasminogen activator), cutting off the nutrient source of the tumor. In the late stage of the tumor, the tumor may metastasize, and fisetin can prevent the degradation of the ECM protein barrier by inhibiting the key target of MMP-1, thereby preventing tumor cells from entering the blood and inhibiting the metastasis of tumor cells.