The lung is an important organ of the human respiratory system. It is mainly responsible for the gas exchange in the body. When the lung function declines, it will not only affect the respiratory system, but also affect the body's water metabolism, blood circulation, immune system and other functions.
The function of the lung is so important, but its decline is much earlier than we think. The peak period of lung maturity and function is 18-25 years old, it remains stable with little change until 35 years old, and gradually declines thereafter.
As we age, our lung function declines year by year, making older adults more susceptible to respiratory-related diseases. According to statistics, the mortality rate of individuals over 80 years old is 20 times or more that of individuals over 50 years old.
In addition to aging, in daily life, many external factors are also constantly increasing the pressure on the lungs, making it age faster: such as smoking, smog, kitchen fumes, virus invasion and so on.
NMN is an important substance that widely exists in organisms and is closely related to NAD+ metabolism. NMN has a wide range of physiological functions, including anti-oxidation, anti-inflammation, anti-aging, etc., so it is of great significance to maintain lung health.
What is the relationship between lung aging and NAD+?
NMN is a precursor to nicotinamide adenine dinucleotide (NAD+), a key molecule in metabolism and DNA health that has been shown to decrease with age in many cell types and organs, including the lung . Age-related diseases such as cardiovascular disease, neurodegenerative disease, and metabolic disorders are all associated with reduced NAD+ levels.
The main role of NMN
• Anti-inflammatory effect of NMN
Inflammation is one of the main pathogenesis factors of lung disease. Prolonged inflammatory responses may lead to airway remodeling, fibrosis, and ultimately lung function decline. NMN can reduce inflammatory damage by inhibiting the inflammatory response.
● Antioxidant effect of NMN
Oxidative stress is an important pathogenesis factor in lung diseases. Excessive oxidative stress can lead to damage to cellular structures, further triggering inflammation and decreased lung function. NMN has a significant antioxidant effect and can effectively remove excess free radicals in the body.
● Anti-fibrotic effect of NMN
Pulmonary fibrosis is a common lung disease characterized by excessive fibrous deposition in the lung parenchyma, eventually leading to decreased lung function. NMN has shown promising therapeutic potential in anti-fibrosis. Studies have confirmed that NMN can reduce the activation and proliferation of lung fibroblasts by inhibiting the TGF-β1/Smad pathway, thereby inhibiting the occurrence of fibrosis. Studies have shown that NMN may become a potential drug with anti-fibrotic effects.
● NMNs regulate immune responses
The immune system plays a key role in maintaining lung health. NMN has the ability to regulate the immune response and can affect the function of immune cells. Studies have shown that NMN can improve the phagocytic ability of macrophages, prompting them to effectively clear infection and inflammatory factors. At the same time, NMN can also regulate the function of T cells, thereby balancing the ratio of Th1/Th2 cells and reducing lung inflammation. These roles in regulating immune function make NMN have broad application prospects in the treatment of lung diseases.
