Raw Tadalafil Powder

Raw Tadalafil Powder is widely used in some medicines which can bring you and your lovers some wonderful experience. And Tadalafil needs to be guided by the stimulation of intimate contact. When the stimulation leads to local release of nitric oxide, PDE5 will be inhibited by tadalafil, which will increase the cGMP level in the corpus cavernosum of the penis, leading to relaxation of smooth muscles, blood flowing into the penile tissues, and erection.

 

Tadalafil is rapidly absorbed after oral administration, and the mean maximum observed plasma concentration (Cmax) is reached in a median time of 2 hours after taking the drug.

The absorption rate and degree of tadalafil are not affected by food, and the time of taking the medicine (morning or evening) has no clinically significant effect on the absorption rate and degree.

 

The average clearance rate of oral tadalafil in healthy subjects is 2.5L/hr, and the average half-life is 17.5 hours. Tadalafil is mainly excreted in the form of inactive metabolites, mainly from feces (about 61% of the dose). Part of it is excreted in urine (about 36% of the dose).

The recommended oral intake is once a day, 10mg each time, if 10mg is not obvious, it can be increased to 20mg, the most effective effect is to take 30 minutes before you want to have an intimate experience with the other.

 

Selective PDE5 Enzyme Inhibition

Competitively inhibits PDE5, suppressing cGMP breakdown in vascular smooth muscles to facilitate sustained enzymatic signaling.

 

Nitric Oxide (NO) / cGMP Pathway Enhancement

Enhances the physiological cascade triggered by endogenous nitric oxide release, resulting in localized arterial relaxation.

 

Extended Pharmacokinetic Half-Life

Exhibits a distinct prolongative terminal elimination half-life (~17.5 hours), supporting long-lasting receptor activity compared to shorter-acting analogues.

 

Smooth Muscle Tone Relaxation

Promotes arterial vasodilation and lowers cellular resistance in corporal, pulmonary, and prostatic vascular beds.

 

High Chemical & Physical Stability

Crystalline structure offers high solid-state stability and predictable dissolution parameters under compliant pharmaceutical processing conditions.

 

Tadalafil API + Microcrystalline Cellulose (MCC) + Lactose Monohydrate (Direct Compression Matrix)

Standard pharmaceutical excipient blend optimizing flowability, compressibility, and uniform drug content in compressed tablets.

 

Tadalafil API + Croscarmellose Sodium + Magnesium Stearate (Rapid Dissolution Oral Complex)

Fast-disintegrating solid dosage formulation engineered for accelerated dissolution and steady bioavailability.

 

Tadalafil API + Hydroxypropyl Methylcellulose (HPMC) (Sustained Release Matrix)

Polymer matrix composition designed for controlled drug release profiles and extended systemic exposure.

 

Most of the side effects are mild and short-lived, which is why tadalafil is better than sildenafil. It should be noted that tadalafil can enhance the blood pressure-lowering effect of nitrate drugs, so you are taking any Patients with forms of nitrate drugs are prohibited from taking tadalafil.

 

The life of intimate contact can bring potential heart risks to patients with heart disease. Therefore, treatment drugs for erectile dysfunction, including tadalafil, are recommended for patients with heart disease who are not suitable for intimate contact.

Alpha-blockers such as doxazosin and tadalafil may cause hypotension when taken at the same time. It is recommended not to use these drugs at the same time

 

Standard packaging: 1 kg/bag, 3-20 kg/box, more than 20 kg/drum, suitable for trial orders and full container shipping.

 

By Express	By Sea	By Air
Suitable for single samples or <50kg Fast: 3-10 days High shipping cost Door to door service	Suitable for >50kg Fast: 3-7 days daysLower than express cost Airport to airport service Professional broker needed	Suitable for > 300kg Slow: Around 30 days Lowest cost Port to port service Professional broker needed

 

Q: What specifications do you offer for bulk orders?

A: Tadalafil API ≥99.0\%$ purity, fully compliant with USP, EP, and BP pharmacopeial standards tested by HPLC. Specs can be adjusted to your target, with COA, MSDS, and microbiological reports provided per batch.

 

Q: What is your MOQ for wholesale orders?

A: Our Raw Tadalafil Powder MOQ starts from 1kg for trial quantities, up to 25kg drums for commercial orders. Flexible terms available for long-term partnerships.

 

Q: How do you ensure quality and stability during shipping?

A: Controlled extraction and drying, packed in moisture-resistant, food-grade packaging. Recommend storing in a cool, dry place away from light.

 

Q: Do you support OEM/private label projects?

A: Yes, including custom excipient pre-blends, particle size micronization, and tablet/capsule processing support for qualifying volumes. Our team can advise on ratios for qualifying volumes.

 

Sheerherb is a specialized manufacturer and global bulk supplier of high-purity Raw Tadalafil Powder API. Our state-of-the-art production facility adheres strictly to ISO 9001, ISO 22000, HALAL, KOSHER, and cGMP standards. We provide full-service OEM/ODM support-from custom micronization to contract packaging and regulatory documentation support. Every single lot undergoes comprehensive HPLC assay testing and quality verification to guarantee maximum stability and compliance.

 

If you're comparing Raw Tadalafil Powder wholesale prices or need a Raw Tadalafil raw material supplier for OEM/private label production, contact chriswang@sheerherb.com for current pricing, COA samples, and a formal quote.