Apigenin Extract (apigenin), also known as apigenin, apigenin. It is a flavonoid compound. It is mainly high in celery.
A large number of studies at home and abroad have found that apigenin has a variety of biological activities such as anti-tumor, cardio-cerebral vascular protection, anti-virus, and anti-bacterial activities.
In recent years, apigenin is particularly important, which is mainly reflected in its carcinogenic activity and antidepressant inhibiting carcinogens; as an antiviral drug for the treatment of HIV and other viral infections
Among a wide variety of phenolic compounds, Apigenin Extract is the most famous one. Scientists have summarized the various therapeutic functions of apigenin through in vitro and in vivo systems. The different mechanisms of apigenin's potential therapeutic effects were explored, including cell cycle arrest, cell apoptosis, anti-inflammatory, and antioxidant functions. It is known that apigenin can regulate the intrinsic apoptotic pathway and change the mitochondrial membrane potential. In cancer cells, apigenin activates apoptosis by regulating the expression of Bcl-2, Bax, STAT-3, and Akt proteins.
Scientists used a certain dose of apigenin to test its effect on depressed mice and found that apigenin has antidepressant-like activity on the conversion of norepinephrine (NE) and dopamine (DA) in the amygdala and hypothalamus of mice. Behavioral tests showed that apigenin reversed the decrease in sucrose preference and the increase in immobility time. In addition, corticosterone-treated mice supplemented with apigenin ameliorated the reduction in hippocampal brain-derived neurotrophic factor (BDNF) levels, emphasizing its antidepressant effect upregulated by BDNF.
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