How to maximize the effect of NMN?

According to Professor David Sinclair, the discoverer of the anti-aging effect of NMN, the results of ten years of physiological tests against growth, NMN is the precursor of NAD+, and nmn exists in food or supplemented with food to help the body replenish NAD+. NAD+ survives in human cells, but with age, NAD+ will decrease, making human cells age. Taking NMN can help the body fully replenish NAD+, thereby making the body younger and delaying aging. NMN is just one way to achieve a higher quality of life like a "centenarian"!

Although scientists have found through research that proanthocyanidins can significantly increase the level of NMN in the body (1+1 anti-aging effect is greater than 2! Unveiling the perfect combination of NMN and proanthocyanidins), they believe that it is necessary to combine a variety of plant compounds to enhance its anti-aging effect.

According to the research of Macau University of Science and Technology, the combination of NMN with resveratrol and ginsenoside can double the effect.

Resveratrol is a polyphenolic compound, mainly derived from plants such as peanuts, grapes (red wine), knotweed, and mulberries. Resveratrol is a kind of natural polyphenols with strong biological properties, also known as stilbene triphenols. chemopreventive agents.
Ginsenoside is a steroid compound, also known as triterpene saponin. It is mainly found in ginseng medicinal materials. Ginsenosides are considered to be the active ingredients in ginseng and thus have been the subject of research.
In May 2019, Russia's Far Eastern Federal University developed a new method for extracting ginsenosides, which can maintain biological activity and improve storage time.
At the 22nd National Congress of Clinical Oncology in 2019, experts and researchers announced the latest progress in anti-tumor angiogenesis therapy. Taking "Ginsenoside Rg3 Drugs Anti-tumor Angiogenesis" as the report topic, the report clarified that ginsenoside Rg3 inhibits tumor angiogenesis by inhibiting the proliferation and migration of vascular endothelial cells, inhibiting VEGF activity and its signal transduction pathway, and inhibiting the degradation of extravascular matrix. The resulting mechanism of action.
Resveratrol and ginsenosides are two such plant compounds found primarily in plants such as peanuts, grapes (red wine), knotweed, mulberries, and ginseng. They have indeed shown promise in slowing some of the aging process, as well as increasing NAD+ levels, according to a series of studies.

There is an inextricable relationship between NMN and resveratrol. The mixture of NMN and resveratrol is not simply a superposition of nutrients. The addition of resveratrol greatly improves the performance of NMN.

● Anti-aging characteristics

In 2003, Harvard University professor David Sinclair and his team found that resveratrol can activate acetylase and increase the lifespan of yeast, which stimulated the upsurge of research on resveratrol anti-aging. Howitz et al. found that resveratrol can act as an activator of SIRT1, which can simulate the anti-aging response of calorie restriction (CR), and participate in the regulation of the average lifespan of organic organisms. CR is a strong inducer of SIRT1, which can increase the expression of SIRT1 in organs and tissues such as brain, heart, intestine, kidney, muscle and fat. CR can cause physiological changes in delaying aging and prolonging lifespan, most notably by 50%. Studies have confirmed that resveratrol can prolong the lifespan of yeast, nematodes, fruit flies and lower fish.

● Enhanced NMN performance

The combination of resveratrol and NMN originated from Professor David Sinclair of Harvard University. He said: "If protein sirtuins are regarded as cars, NAD+ is the fuel, then resveratrol is the accelerator pedal." This sentence is very good The role of NMN with resveratrol is explained.

Since the NAD+ molecule is too large, it cannot directly enter the cells and be absorbed by the human body, so the NAD+ level can only be increased by taking NAD+ precursors. As the most direct and effective precursor of NAD+, NMN can be converted into NAD in the body to activate SIRT protein, and the addition of resveratrol greatly improves the bioavailability of NMN. The combination of NMN and resveratrol presents The effect of "1+1>2" is achieved, and the effect of NAD+ is exerted to a greater extent.

He believes that the combination of NMN and resveratrol makes the "car" of Sirtuins run faster and have a better anti-aging effect. The activation effect of NMN and resveratrol on Sirtuins is emphasized.

And the third compound investigated in this study is the ginsenoside family - the main active compounds found in ginseng.
In fact, the potential of ginsenosides in immunomodulation, anti-tumor and anti-aging has been attracting much attention. Moreover, studies have found that ginsenosides can regulate nicotinamide phosphoribosyltransferase (NAMPT) to maintain mitochondrial function, and NAMPT transferase just plays an important role in the NAD + salvage synthesis pathway, helping to increase the level of NMN in the body.
Compared with NMN, the research on ginsenoside protector takes longer and has a thicker historical background. Since ancient times, ginseng has been a traditional Chinese medicine for invigorating the middle and nourishing qi, and is synonymous with health and longevity. This has been further confirmed in modern research. In the 1980s, Japanese scholars first discovered ginsenoside Rh2. Since then, many research results have shown that Its efficacy also proves the benefits of ginseng to the human body from a scientific point of view. Later today, ginsenoside Rh2 is called the life-protecting element, which is enough to see the recognition and affirmation of the public.
Many experiments and documents at home and abroad have confirmed that ginsenoside Rh2 can regulate and enhance the immune function of the body through various ways, and has a protective effect on the immune system. Ginsenoside Rh2 can significantly increase the activity of IL-2, improve the phagocytosis of macrophages and the killing activity of NK cells. At the same time, it can act as an immune regulator, promote the synthesis of albumin and gamma globulin, improve the function of T cells and macrophages, inhibit normal lymphocyte chromosome mutations, and stabilize the immune system.

The research team of Macau University of Science and Technology published their research results in "Pharmacology Research & Perspectives". They studied the effect of NMN combined with some dietary supplements on NAD+ levels, including resveratrol and ginsenosides Rg3 and Rh2. The results showed that NMN combined with Use can increase NAD+ levels in specific tissues and organs. The researchers divided the experimental mice into 4 groups, the control group, the NMN group, the NMN+resveratrol group (NMN+R), and the NMN+ginsenoside Rg3&Rh2 group (NMN+G).

● NMN combined with resveratrol or ginsenosides improves the distribution of NMN in tissues

The researchers measured the concentration of NMN in different tissues 1, 2, 4, and 6 hours after oral administration, and found that after NMN was used alone, NMN mainly accumulated in the liver, and the NMN level in the heart increased by 1.39 times after being combined with resveratrol.
After combined with ginsenosides Rg3 and Rh2, the distribution efficiency of NMN in the brain, heart, kidney and lung was significantly improved. It indicated that the combination of NMN may improve its distribution among tissues.

● The combined application of NMN with resveratrol or ginsenosides increases the level of NAD + in body tissues

We know that NMN is converted into NAD+ in the body to exert a series of anti-aging effects. Then, in addition to improving the NMN level in the organization, can the combined use also increase the NAD+ level in the organization?

NAD+ levels in the liver and kidney were significantly increased after oral administration of NMN alone compared to the control group.
Compared with NMN alone, the combination of NMN and resveratrol increased the NAD+ levels in the heart and skeletal muscle by 1.59 times and 1.72 times, respectively, which can reduce cardiac hypertrophy and protect the heart to a certain extent, while the NAD+ levels of muscles Increased levels can reduce muscle damage, inflammation and fibrosis.

However, when NMN was used in combination with ginsenoside, the NAD+ level in the lung tissue increased significantly by 1.97 times, which also indicated that the combined use of NMN and ginsenoside was effective for lung cell aging induced by natural aging of the lung or by external factors such as smoking. There is a more positive improvement effect.