2-Hydroxybenzylamine

What Is 2-HOBA?
2-HOBA is a compound that occurs naturally in the buckwheat plant. It was originally discovered by scientists at Vanderbilt University through research led by Naji Abumrad, MD. 2-HOBA is a natural compound touted as "the only nutritional intervention known to date that specifically targets the negative effects of oxidative stress" without impairing the body's normal, healthy processes.

1.ROS
In a biological context, ROS are formed as natural byproducts of the normal metabolism of oxygen and have important roles in cell signaling and homeostasis. The latest findings suggest that optimal cellular health comes from a balance between ROS formation and removal, rather than efforts to eliminate ROS.

There are two sources of ROS that can affect cells: endogenous and exogenous. Endogenous ROS are normal, natural byproducts of mitochondrial oxygen metabolism. Exogenous ROS come from environmental sources such as smoking, pollution, UV light and alcohol consumption.
2.Oxidative stress
ROS levels increase dramatically during environmental stress (e.g., UV or heat exposure). This can cause serious damage to cellular structures, which is known as oxidative stress. Excessive oxidative stress often leads to disruption of the normal function of cells. However, some oxidative stress is important to the normal function of the body, so completely blocking oxidative stress is not feasible.
3.ISOLGS
Damage occurs when ROS react with lipids and produce a highly reactive molecule called IsoLG. IsoLGs are one of the common downstream products of oxidative stress.
2-HOBA is positioned to neutralize IsoLGs before they have a chance to react with DNA, proteins, and other delicate cellular components. It reduces the expression of inflammatory cytokines and increases the expression of anti-inflammatory cytokines, thereby helping to maintain a healthy immune system balance.

2-HOBA rapidly captures specific compounds formed by oxidative stress (such as Isveramectin) and prevents them from binding to cellular components (proteins, lipids or DNA), thereby maintaining the normal function of these components.
2-HOBA has been shown to protect brain cells, blood vessels, and heart, lung, and immune system cells from oxidative stress, which helps support healthy function.
2-HOBA sequesters IsoLG extremely rapidly and prevents downstream modifications of DNA and proteins.

We supply high-quality 2-HOBA and process it into capsules, tablets, powder in bags, etc.